Abstract 11713: Prevalence and Associated Metabolic Factors of Non-alcoholic Fatty Liver Disease in Acute Stroke Patients Aged 40-79 Years

Introduction:Non-alcoholic fatty liver disease (NAFLD) is reported to be a predictor of cardiovascular disease (CD). However, prevalence and associated metabolic factors of NAFLD in acute stroke middle and old-aged patients remain unknown.Hypothesis:In acute stroke patients aged 40-79 years, prevalence of NAFLD on admission is high and its metabolic factors are body mass index (BMI), triglycerides (TG), some fatty acids, blood sugar or HbA1c and aspartate aminotransferase / alanine aminotransferase ratio (AST/ALT ratio) as well as reported in ischemic heart disease.Methods:We included acute stroke patients who 1) were admitted from August 2016 to July 2017 and aged 40-79 years, 2) underwent abdominal ultrasonography and 3) took blood examination of serum fatty acids on admission. We evaluated prevalence and associated metabolic factors of non-alcoholic fatty liver disease.Results:Among 582 acute stroke patients, 273 patients met our inclusive criteria. Their median age was 70 years, 108 patients (39.6%) had NAFLD. In NAFLD and non-NAFLD patients, median age was 68 and 71 years (p<0.05), BMI was 24.8 and 21.9 kg/m2(p<0.0001), Alb was 4.2 and 4.0 g/dl (p<0.01), HbA1c was 7.0 and 6.1 % (p<0.05), T-CHO was 214.7 and 197.7 mg/dl (p<0.01), TG was 181.8 and 115.0 mg/dl (p<0.0001), palmitic acid (PA) was 826.6 and 680.3 ?g/ml (p<0.0001), oleic acid (OA) was 802.9 and 632.2 ?g/ml (p<0.0001), linoleic acid (LiA) was 854.7 and 781.8 ?g/ml (p<0.05), dihomo-gamma-linolenic acid (DGLA) was 35.8 and 28.5 ?g/ml (p<0.0001) and AST/ALT ratio was 1.05 and 1.38 (p<0.0001), respectively. Multiple stepwise regression analysis showed that BMI, DGLA and AST/ALT ratio were independent factors of NAFLD. Receiver operating characteristic (ROC) curves for NAFLD showed that cut-off values of BMI, DGLA and AST/ALT ratio were 22.2 or more, 30.1 or more and 1.29 or less, respectively.Conclusions:In acute stroke patients aged 40-79 years, prevalence of NAFLD on admission was high and independent metabolic factors of NAFLD were higher BMI, higher DGLA (20:3, n-6) and lower AST/ALT ratio.