Abstract P279: Prevalence and Independent Metabolic Factors of Non-alcoholic Fatty Liver Disease in Acute Stroke Patients Aged 40-79 Years

Introduction:Non-alcoholic fatty liver disease (NAFLD) is reported to be a predictor of cardiovascular disease (CD). NAFLD is probably associated with stroke in middle and old-aged patients.Hypothesis:In acute stroke patients aged 40-79 years, prevalence of NAFLD on admission is high and its metabolic factors are body mass index (BMI), triglycerides (TG), some fatty acids, blood sugar or HbA1c and aspartate aminotransferase / alanine aminotransferase ratio (AST/ALT ratio) as well as reported in ischemic heart disease.Methods:We included acute stroke patients aged 40-79 years who 1) were admitted from August 2016 to July 2019 within 24 hours of onset, 2) underwent abdominal ultrasonography and 3) took blood examination of serum fatty acids on admission. We evaluated prevalence and associated metabolic factors of non-alcoholic fatty liver disease.Results:Among 1672 acute stroke patients, 676 patients met our inclusive criteria. Their median age was 70 years, 267 patients (39.5%) had NAFLD. In NAFLD and non-NAFLD patients, median age was 68 and 71 years (p<0.0001), BMI was 24.8 and 21.6 kg/m2(p<0.0001), Alb was 4.2 and 4.0 g/dl (p<0.0001), HbA1c was 6.0 and 5.8 % (p<0.0001), T-CHO was 206 and 198 mg/dl (p<0.05), TG was 135 and 93 mg/dl (p<0.0001), palmitic acid (PA) was 727 and 627.4 μg/ml (p<0.0001), oleic acid (OA) was 672.6 and 563.1 μg/ml (p<0.0001), linoleic acid (LiA) was 772.3 and 730.2 μg/ml (p<0.05), dihomo-gamma-linolenic acid (DGLA) was 34.1 and 26.5 μg/ml (p<0.0001) and AST/ALT ratio was 1.09 and 1.36 (p<0.0001), respectively.Conclusions:In acute stroke patients aged 40-79 years, prevalence of NAFLD on admission was high and metabolic factors of NAFLD were younger Age, higher BMI, higher serum concentrations of Alb, T-CHO, TG and fatty acids, higher HbA1c and lower AST/ALT ratio.