Cetyltrimethylammonium Bromide-Enhanced Chemiluminescence Determination of Uric Acid Using a Luminol-Hexacyanoferrate(III)-Hexacyanoferrate(II) System

A chemiluminescence (CL) method using flow injection (FI) was developed for the determination of uric acid based on the enhancement chemiluminescence intensity of luminol–hexacyanoferrate(III)–hexacyanoferrate(II) in the presence of cetyltrimethylammonium bromide and the uric acid species. The linear range was 7.0 × 10–10–9.0 × 10–7M with a detection limit (3σ) of 2.58 × 10–10M, which was about two orders of magnitude lower than those reported. The proposed method was used for the determination of uric acid in real samples.