Human response against NP-4, a mouse antibody to carcinoembryonic antigen: human anti-idiotype antibodies mimic an epitope on the tumor antigen.

Authors :: Losman, M J
Hansen, H J
Sharkey, R M
Goldenberg, D M
Monestier, M
Source :: Proceedings of the National Academy of Sciences of the United States of America; April 1991, Vol. 88 Issue: 8 p3421-3425, 5p
Publication Year :: 1991
Abstract: Anti-idiotype antibodies (Ab2) were purified from a cancer patient treated with NP-4, a murine monoclonal antibody to carcinoembryonic antigen (CEA). These Ab2 were specific for NP-4 and inhibited the binding between NP-4 and CEA. BALB/c mice immunized with these human Ab2 produced anti-Ab2 antibodies that were also reactive with the CEA epitope recognized by NP-4. These results indicate that human Ab2 to NP-4 can antigenically mimic the CEA epitope recognized by NP-4.

Language :: English
ISSN :: 00278424 and 10916490
Volume :: 88
Issue :: 8
Database :: Supplemental Index
Journal :: Proceedings of the National Academy of Sciences of the United States of America
Publication Type :: Periodical
Accession number :: ejs60447063
Full Text :: https://doi.org/10.1073/pnas.88.8.3421

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