Six mRNAs with different 5' ends are encoded by a single gamma-glutamyltransferase gene in mouse.

Authors :: Rajagopalan, S
Wan, D F
Habib, G M
Sepulveda, A R
McLeod, M R
Lebovitz, R M
Lieberman, M W
Source :: Proceedings of the National Academy of Sciences of the United States of America; July 1993, Vol. 90 Issue: 13 p6179-6183, 5p
Publication Year :: 1993
Abstract: The 5' region of the mouse gamma-glutamyltransferase (gamma GT; EC 2.3.2.2) gene has been cloned and analyzed. This analysis, combined with sequence information obtained from gamma GT cDNA clones, indicates that in mouse a single gamma GT gene codes for six different mRNAs that differ in their 5' sequences. Analysis of steady-state levels of gamma GT RNA reveals different expression patterns for these RNAs in different organs. The six different 5' sequences are widely separated within a 10-kb region and three of them show 75-86% identify with the three known rat gamma GT cDNAs. Although the heterogeneity of the 5' ends of gamma GT RNAs may be explained in part by alternative splicing, it is likely that multiple promoters are involved in their generation.

Language :: English
ISSN :: 00278424 and 10916490
Volume :: 90
Issue :: 13
Database :: Supplemental Index
Journal :: Proceedings of the National Academy of Sciences of the United States of America
Publication Type :: Periodical
Accession number :: ejs60455542
Full Text :: https://doi.org/10.1073/pnas.90.13.6179

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