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Selective killing of T lymphocytes by phototoxic liposomes.
- Source :
- Proceedings of the National Academy of Sciences of the United States of America; January 1987, Vol. 84 Issue: 1 p246-250, 5p
- Publication Year :
- 1987
-
Abstract
- Two-fold specificity in drug delivery obtained through the localized activation of drugs by physical means and the attachment of drugs to proteins that bind to target cells might be used for highly selective cancer chemotherapy or for immunosuppression. Toward this end, a monoclonal antibody against an antigen on the surface of T lymphocytes was covalently attached to liposomes containing a phototoxic drug, pyrene, bound to the lipid bilayer. When unfractionated peripheral blood lymphocytes, or B- and T-cell lines, were irradiated after treatment with these liposomes, T cells were killed while B cells were spared, demonstrating the validity of the approach in a simple in vitro assay.
Details
- Language :
- English
- ISSN :
- 00278424 and 10916490
- Volume :
- 84
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Periodical
- Accession number :
- ejs60457885
- Full Text :
- https://doi.org/10.1073/pnas.84.1.246