Nature‐Derived Okra Gel as Strong Hemostatic Bioadhesive in Human Blood, Liver, and Heart Trauma of Rabbits and Dogs

Bioadhesive performance can be compromised due to bleeding. Bleeding increases mortality. Adhesives with hemostatic function are of great significance. A sustainable and robust hemostatic bioadhesive from okra is reported. The adhesive strength reaches around three and six‐fold higher than commercial fibrin on pigskin and glass, respectively. The okra gel presents high‐pressure resistance and great underwater adhesive strength. In human blood experiments, the okra gel can activate platelets, enhance the adhesion of activated platelets, and release coagulation factors XI and XII. By forming a fast gel layer and closely adhering to the wound, it can quickly stop bleeding in the liver and heart of rabbits and dogs. Meanwhile, okra gel can cause platelet activation at the wound site and further strengthen its hemostatic performance. It is biocompatible, biodegradable, and can promote wound healing and shows potential as a sustainable bioadhesive, especially in the scenario of significant hemorrhage. The work reports a robust hemostatic bioadhesive gel from okra. Okra gel is biocompatible and biodegradable. It promotes wound healing. The gel can activate platelets and release the coagulation factors XI and XII, which leads to a strong hemostatic efficiency. The okra gel shows efficay in treating the bleeding trauma model of the liver and the heart of rabbits and beagle dogs.