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Sinudenoids A–E, C19-Norcembranoid Diterpenes with Unusual Scaffolds from the Soft Coral Sinularia densa
- Source :
- Organic Letters; December 2022, Vol. 24 Issue: 49 p9007-9011, 5p
- Publication Year :
- 2022
-
Abstract
- Five new furanobutenolide-derived C19-norcembranoid diterpenes, sinudenoids A–E (1–5, respectively), were isolated from the soft coral Sinularia densa. Sinudenoid A (1) possesses an uncommon 5/5/11-fused tricyclic ring system. Sinudenoids B–D (2–4, respectively) share the same tetracyclic 5/5/6/6 ring system but represent two kinds of new skeletons. Sinudenoid E (5) is the second compound with the rare 8/8 bicyclic carbon core. A plausible biosynthesis pathway for compounds 1–6is proposed. Compound 5exhibits strong anti-inflammatory activity in the zebrafish model.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 24
- Issue :
- 49
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs61313188
- Full Text :
- https://doi.org/10.1021/acs.orglett.2c03631