Volumetric brain changes in MOGAD: A cross-sectional and longitudinal comparative analysis

•The information regarding the pattern and amount of brain atrophy in MOGAD is currently very limited.•We compared cross-sectional brain volume measures in clinically stable MOGAD to MS, NMOSD and HC, and longitudinal trajectories of brain volume changes in a subset of clinically stable MOGAD, MS and NMOSD patients.•We found a distinct pattern of brain atrophy in MOGAD, suggesting that a subclinical neurodegenerative process may occur in this rare condition.•Our findings may shed light on the distinct pathogenic mechanisms underlying the various neuroinflammatory CNS diseases.