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Engineering naturally occurring CD7−T cells for the immunotherapy of hematological malignancies
- Source :
- Blood; December 2022, Vol. 140 Issue: 25 p2684-2696, 13p
- Publication Year :
- 2022
-
Abstract
- •Naturally occurring CD7 negative T cells are functional effector T cells that can be used for chimeric antigen receptor therapy.•CD7 negative T cells expressing a CD7-CAR have robust antitumor activity and bypass fratricide.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Volume :
- 140
- Issue :
- 25
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs61449060
- Full Text :
- https://doi.org/10.1182/blood.2021015020