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Observation of topological action potentials in engineered tissues

Authors :
Ori, Hillel
Duque, Marc
Frank Hayward, Rebecca
Scheibner, Colin
Tian, He
Ortiz, Gloria
Vitelli, Vincenzo
Cohen, Adam E.
Source :
Nature Physics; February 2023, Vol. 19 Issue: 2 p290-296, 7p
Publication Year :
2023

Abstract

The interface between two tissues can have very different bioelectrical properties compared to either tissue on its own. Here we show that an interface between non-excitable tissues can be electrically excitable because of an interaction between the currents passing through the gap junctions—electrically resistive intercellular connections—and the non-linear current–voltage dependence in the ion channels on either side of the interface. Our theory shows that this topologically robust excitability occurs over a far larger range of ion channel expression levels than can support excitability in the bulk. The corresponding interfacial action potentials can cause local elevations in calcium concentration, possibly providing a bioelectrical mechanism for interface sensing. The observed topological action potentials point to the possibility of other types of topological effect in electrophysiology and at other diffusively coupled interfaces.

Details

Language :
English
ISSN :
17452473 and 17452481
Volume :
19
Issue :
2
Database :
Supplemental Index
Journal :
Nature Physics
Publication Type :
Periodical
Accession number :
ejs61520507
Full Text :
https://doi.org/10.1038/s41567-022-01853-z