Comparison of 10 and 14 days of antofloxacin-based versus 14 days of clarithromycin-based bismuth quadruple therapy for Helicobacter pylorieradication: A randomized trial

•Previous study has revealed that 14-days antofloxacin-based bismuth quadruple therapy was safe and effective for H. pylorieradication.•We further confirmed that the H. pylorieradication rate with ANT14 therapy was higher than with ANT10 and CLA14 therapy without significantly increasing the rates of adverse event in the study.•Meanwhile, longer durations have significantly higher eradication rates in patients with antibiotic-resistant strains or antibiotic-susceptible strains.•14 days of antofloxacin-based bismuth quadruple therapy may be a more effective way as the first-line treatment for H. pylori infection.