Decreasing Incidence of the Multisystem Inflammatory Syndrome in Children Over 3 Pandemic Waves

In this nationwide retrospective study, a substantial decline in the incidence of multisystem inflammatory syndrome in children over 3 successive pandemic waves characterized by different severe acute respiratory syndrome coronavirus 2 variants was documented—from 3.4 of 1000 to 1.1 of 1000 and finally to 0.25 of 1000 confirmed severe acute respiratory syndrome coronavirus 2 positive cases (P< 0.0001), respectively, whereas clinical findings and severity did not significantly vary.