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BDNFrs6265 Genotype Influences Outcomes of Pharmacotherapy and Subthalamic Nucleus Deep Brain Stimulation in Early-Stage Parkinson's Disease
- Source :
- Neuromodulation: Technology at the Neural Interface; August 2022, Vol. 25 Issue: 6 p846-853, 8p
- Publication Year :
- 2022
-
Abstract
- The efficacy of pharmacotherapy and deep brain stimulation of the subthalamic nucleus in treating Parkinson's disease motor symptoms is highly variable and may be influenced by patient genotype. The relatively common (prevalence about one in three) and protein-altering rs6265 single nucleotide polymorphism (C > T) in the gene BDNFhas been associated with different clinical outcomes with levodopa.
Details
- Language :
- English
- ISSN :
- 10947159 and 15251403
- Volume :
- 25
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Neuromodulation: Technology at the Neural Interface
- Publication Type :
- Periodical
- Accession number :
- ejs61848711
- Full Text :
- https://doi.org/10.1111/ner.13504