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A CASE SERIES OF HLA-B*58:01 SPECIFIC ALLOPURINOL-INDUCED DRESS/DIHS

Authors :
Diaz, A.
Sani, S.
Mawhirt, S.
Banta, E.
Fonacier, L.
Source :
Annals of Allergy, Asthma & Immunology; November 2022, Vol. 129 Issue: 5, Number 5 Supplement 1 pS97-S98, 2p
Publication Year :
2022

Abstract

Drug reaction with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS) represents a severe adverse drug reaction with a high mortality rate. Allopurinol-induced DRESS/DIHS can be associated with polymorphisms in human leukocyte antigen (HLA) genes, with higher prevalence of the HLA-B*58:01 allele in Asians (7.4%) and Africans (3.8%) compared to other ethnic populations.

Details

Language :
English
ISSN :
10811206
Volume :
129
Issue :
5, Number 5 Supplement 1
Database :
Supplemental Index
Journal :
Annals of Allergy, Asthma & Immunology
Publication Type :
Periodical
Accession number :
ejs61919129
Full Text :
https://doi.org/10.1016/j.anai.2022.08.776