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Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations

Authors :
Temprano‐Sagrera, Gerard
Sitlani, Colleen M.
Bone, William P.
Martin‐Bornez, Miguel
Voight, Benjamin F.
Morrison, Alanna C.
Damrauer, Scott M.
de Vries, Paul S.
Smith, Nicholas L.
Sabater‐Lleal, Maria
Dehghan, Abbas
Heath, Adam S
Morrison, Alanna C
Reiner, Alex P
Johnson, Andrew
Richmond, Anne
Peters, Annette
van Hylckama Vlieg, Astrid
McKnight, Barbara
Psaty, Bruce M
Hayward, Caroline
Ward‐Caviness, Cavin
O’Donnell, Christopher
Chasman, Daniel
Strachan, David P
Tregouet, David A
Mook‐Kanamori, Dennis
Gill, Dipender
Thibord, Florian
Asselbergs, Folkert W
Leebeek, Frank W.G.
Rosendaal, Frits R
Davies, Gail
Homuth, Georg
Temprano, Gerard
Campbell, Harry
Taylor, Herman A
Bressler, Jan
Huffman, Jennifer E
Rotter, Jerome I
Yao, Jie
Wilson, James F
Bis, Joshua C
Hahn, Julie M
Desch, Karl C
Wiggins, Kerri L
Raffield, Laura M
Bielak, Lawrence F
Yanek, Lisa R
Kleber, Marcus E
Sabater‐Lleal, Maria
Mueller, Martina
Kavousi, Maryam
Mangino, Massimo
Liu, Melissa
Brown, Michael R
Conomos, Matthew P
Jhun, Min‐A
Chen, Ming‐Huei
de Maat, Moniek P.M.
Pankratz, Nathan
Smith, Nicholas L
Peyser, Patricia A
Elliot, Paul
de Vries, Paul S
Wei, Peng
Wild, Philipp S
Morange, Pierre E
van der Harst, Pim
Yang, Qiong
Le, Ngoc‐Quynh
Marioni, Riccardo
Li, Ruifang
Damrauer, Scott M
Cox, Simon R
Trompet, Stella
Felix, Stephan B
Völker, Uwe
Tang, Weihong
Koenig, Wolfgang
Jukema, J. Wouter
Guo, Xiuqing
Lindstrom, Sara
Wang, Lu
Smith, Erin N
Gordon, William
van Hylckama Vlieg, Astrid
de Andrade, Mariza
Brody, Jennifer A
Pattee, Jack W
Haessler, Jeffrey
Brumpton, Ben M
Chasman, Daniel I
Suchon, Pierre
Chen, Ming‐Huei
Turman, Constance
Germain, Marine
Wiggins, Kerri L
MacDonald, James
Braekkan, Sigrid K
Armasu, Sebastian M
Pankratz, Nathan
Jackson, Rabecca D
Nielsen, Jonas B
Giulianini, Franco
Puurunen, Marja K
Ibrahim, Manal
Heckbert, Susan R
Bammler, Theo K
Frazer, Kelly A
McCauley, Bryan M
Taylor, Kent
Pankow, James S
Reiner, Alexander P
Gabrielsen, Maiken E
Deleuze, Jean‐François
O’Donnell, Chris J
Kim, Jihye
McKnight, Barbara
Kraft, Peter
Hansen, John‐Bjarne
Rosendaal, Frits R
Heit, John A
Psaty, Bruce M
Tang, Weihong
Kooperberg, Charles
Hveem, Kristian
Ridker, Paul M
Morange, Pierre‐Emmanuel
Johnson, Andrew D
Kabrhel, Christopher
Trégouët, David‐Alexandre
Smith, Nicholas L
Malik, Rainer
Chauhan, Ganesh
Traylor, Matthew
Sargurupremraj, Muralidharan
Okada, Yukinori
Mishra, Aniket
Rutten‐Jacobs, Loes
Giese, Anne‐Katrin
van der Laan, Sander W
Gretarsdottir, Solveig
Anderson, Christopher D
Chong, Michael
Adams, Hieab HH
Ago, Tetsuro
Almgren, Peter
Amouyel, Philippe
Ay, Hakan
Bartz, Traci M
Benavente, Oscar R
Bevan, Steve
Boncoraglio, Giorgio B
Brown, Robert D
Butterworth, Adam S
Carrera, Caty
Carty, Cara L
Chasman, Daniel I
Chen, Wei‐Min
Cole, John W
Correa, Adolfo
Cotlarciuc, Ioana
Cruchaga, Carlos
Danesh, John
de Bakker, Paul IW
DeStefano, Anita L
den Hoed, Marcel
Duan, Qing
Engelter, Stefan T
Falcone, Guido J
Gottesman, Rebecca F
Grewal, Raji P
Gudnason, Vilmundur
Gustafsson, Stefan
Haessler, Jeffrey
Harris, Tamara B
Hassan, Ahamad
Havulinna, Aki S
Heckbert, Susan R
Holliday, Elizabeth G
Howard, George
Hsu, Fang‐Chi
Hyacinth, Hyacinth I
Arfan Ikram, M
Ingelsson, Erik
Irvin, Marguerite R
Jian, Xueqiu
Jiménez‐Conde, Jordi
Johnson, Julie A
Jukema, J Wouter
Kanai, Masahiro
Keene, Keith L
Kissela, Brett M
Kleindorfer, Dawn O
Kooperberg, Charles
Kubo, Michiaki
Lange, Leslie A
Langefeld, Carl D
Langenberg, Claudia
Launer, Lenore J
Lee, Jin‐Moo
Lemmens, Robin
Leys, Didier
Lewis, Cathryn M
Lin, Wei‐Yu
Lindgren, Arne G
Lorentzen, Erik
Magnusson, Patrik K
Maguire, Jane
Manichaikul, Ani
McArdle, Patrick F
Meschia, James F
Mitchell, Braxton D
Mosley, Thomas H
Nalls, Michael A
Ninomiya, Toshiharu
O’Donnell, Martin J
Psaty, Bruce M
Pulit, Sara L
Rannikmäe, Kristiina
Reiner, Alexander P
Rexrode, Kathryn M
Rice, Kenneth
Rich, Stephen S
Ridker, Paul M
Rost, Natalia S
Rothwell, Peter M
Rotter, Jerome I
Rundek, Tatjana
Sacco, Ralph L
Sakaue, Saori
Sale, Michele M
Salomaa, Veikko
Sapkota, Bishwa R
Schmidt, Reinhold
Schmidt, Carsten O
Schminke, Ulf
Sharma, Pankaj
Slowik, Agnieszka
Sudlow, Cathie LM
Tanislav, Christian
Tatlisumak, Turgut
Taylor, Kent D
Thijs, Vincent NS
Thorleifsson, Gudmar
Thorsteinsdottir, Unnur
Tiedt, Steffen
Trompet, Stella
Tzourio, Christophe
van Duijn, Cornelia M
Walters, Matthew
Wareham, Nicholas J
Wassertheil‐Smoller, Sylvia
Wilson, James G
Wiggins, Kerri L
Yang, Qiong
Yusuf, Salim
Amin, Najaf
Aparicio, Hugo S
Arnett, Donna K
Attia, John
Beiser, Alexa S
Berr, Claudine
Buring, Julie E
Bustamante, Mariana
Caso, Valeria
Cheng, Yu‐Ching
Hoan Choi, Seung
Chowhan, Ayesha
Cullell, Natalia
Dartigues, Jean‐François
Delavaran, Hossein
Delgado, Pilar
Dörr, Marcus
Engström, Gunnar
Ford, Ian
Gurpreet, Wander S
Hamsten, Anders
Heitsch, Laura
Hozawa, Atsushi
Ibanez, Laura
Ilinca, Andreea
Ingelsson, Martin
Iwasaki, Motoki
Jackson, Rebecca D
Jood, Katarina
Jousilahti, Pekka
Kaffashian, Sara
Kalra, Lalit
Kamouchi, Masahiro
Kitazono, Takanari
Kjartansson, Olafur
Kloss, Manja
Koudstaal, Peter J
Krupinski, Jerzy
Labovitz, Daniel L
Laurie, Cathy C
Levi, Christopher R
Li, Linxin
Lind, Lars
Lindgren, Cecilia M
Lioutas, Vasileios
Mei Liu, Yong
Lopez, Oscar L
Makoto, Hirata
Martinez‐Majander, Nicolas
Matsuda, Koichi
Minegishi, Naoko
Montaner, Joan
Morris, Andrew P
Muiño, Elena
Müller‐Nurasyid, Martina
Norrving, Bo
Ogishima, Soichi
Parati, Eugenio A
Reddy Peddareddygari, Leema
Pedersen, Nancy L
Pera, Joanna
Perola, Markus
Pezzini, Alessandro
Pileggi, Silvana
Rabionet, Raquel
Riba‐Llena, Iolanda
Ribasés, Marta
Romero, Jose R
Roquer, Jaume
Rudd, Anthony G
Sarin, Antti‐Pekka
Sarju, Ralhan
Sarnowski, Chloe
Sasaki, Makoto
Satizabal, Claudia L
Satoh, Mamoru
Sattar, Naveed
Sawada, Norie
Sibolt, Gerli
Sigurdsson, Ásgeir
Smith, Albert
Sobue, Kenji
Soriano‐Tárraga, Carolina
Stanne, Tara
Colin Stine, O
Stott, David J
Strauch, Konstantin
Takai, Takako
Tanaka, Hideo
Tanno, Kozo
Teumer, Alexander
Tomppo, Liisa
Torres‐Aguila, Nuria P
Touze, Emmanuel
Tsugane, Shoichiro
Uitterlinden, Andre G
Valdimarsson, Einar M
van der Lee, Sven J
Völzke, Henry
Wakai, Kenji
Weir, David
Williams, Stephen R
Wolfe, Charles DA
Wong, Quenna
Xu, Huichun
Yamaji, Taiki
Sanghera, Dharambir K
Melander, Olle
Jern, Christina
Strbian, Daniel
Fernandez‐Cadenas, Israel
Longstreth, W T
Rolfs, Arndt
Hata, Jun
Woo, Daniel
Rosand, Jonathan
Pare, Guillaume
Hopewell, Jemma C
Saleheen, Danish
Stefansson, Kari
Worrall, Bradford B
Kittner, Steven J
Seshadri, Sudha
Fornage, Myriam
Markus, Hugh S
Howson, Joanna MM
Kamatani, Yoichiro
Debette, Stephanie
Dichgans, Martin
Source :
Journal of Thrombosis and Haemostasis; June 2022, Vol. 20 Issue: 6 p1331-1349, 19p
Publication Year :
2022

Abstract

Multi‐phenotype analysis of genetically correlated phenotypes can increase the statistical power to detect loci associated with multiple traits, leading to the discovery of novel loci. This is the first study to date to comprehensively analyze the shared genetic effects within different hemostatic traits, and between these and their associated disease outcomes.

Details

Language :
English
ISSN :
15387933 and 15387836
Volume :
20
Issue :
6
Database :
Supplemental Index
Journal :
Journal of Thrombosis and Haemostasis
Publication Type :
Periodical
Accession number :
ejs62063978
Full Text :
https://doi.org/10.1111/jth.15698