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The Chinese herbal prescription JieZe-1 inhibits caspase-1-dependent pyroptosis induced by herpes simplex virus-2 infection in vitro

Authors :
Liu, Tong
Shao, Qing-qing
Wang, Wen-jia
Liu, Tian-li
Jin, Xi-ming
Xu, Li-jun
Huang, Guang-ying
Chen, Zhuo
Source :
Journal of Integrative Medicine (JIM); May 2023, Vol. 21 Issue: 3 p277-288, 12p
Publication Year :
2023

Abstract

JieZe-1 (JZ-1), a Chinese herbal prescription, has an obvious effect on genital herpes, which is mainly caused by herpes simplex virus type 2 (HSV-2). Our study aimed to address whether HSV-2 induces pyroptosis of VK2/E6E7 cells and to investigate the anti-HSV-2 activity of JZ-1 and the effect of JZ-1 on caspase-1-dependent pyroptosis.

Details

Language :
English
ISSN :
20954964
Volume :
21
Issue :
3
Database :
Supplemental Index
Journal :
Journal of Integrative Medicine (JIM)
Publication Type :
Periodical
Accession number :
ejs62463769
Full Text :
https://doi.org/10.1016/j.joim.2023.03.003