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Molecular basis of polycomb group protein-mediated fetal hemoglobin repression
- Source :
- Blood; 20230101, Issue: Preprints
- Publication Year :
- 2023
-
Abstract
- •A CRISPR-Cas9 screen for HbF repressors identified polycomb protein BMI1, which is found to function within the canonical PRC1 complex.•RNA binding proteins LIN28B, IGF2BP1, and IGF2BP3 are the critical links between PRC1 and HbF repression in adult-type erythroid cells.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs62529386
- Full Text :
- https://doi.org/10.1182/blood.2022019578