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Cell-Free DNA Dynamic Concentration and Other Variables Are Predictors of Early Progression after Chimeric Antigen Receptor T Cell Therapy in Patients with Diffuse Large B Cell Lymphoma
- Source :
- Transplantation and Cellular Therapy; 20230101, Issue: Preprints
- Publication Year :
- 2023
-
Abstract
- •We propose a novel biomarker that could identify patients with high risk of early progression after chimeric antigen receptor (CAR) T cell therapy.•∆cfDNA (pre-apheresis, [PA] and pre-lymphodepletion [PL]) allows monitoring of tumor dynamics.•∆cfDNA, C-reactive protein, and lactate dehydrogenase levels PL, progression status PL, and male sex were highly correlated with rapid progression after CAR T cell therapy.
Details
- Language :
- English
- ISSN :
- 26666375 and 26666367
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Transplantation and Cellular Therapy
- Publication Type :
- Periodical
- Accession number :
- ejs62533329
- Full Text :
- https://doi.org/10.1016/j.jtct.2023.03.009