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Analysis of the clinical characteristics of dabigatran-induced oesophagitis
- Source :
- European Journal of Hospital Pharmacy : Science and Practice; 2023, Vol. 30 Issue: 1 pe24-e28, 5p
- Publication Year :
- 2023
-
Abstract
- ObjectivesDabigatran-induced oesophagitis has emerged in recent years. However, the incidence and clinical characteristics of patients with dabigatran-induced oesophagitis have not yet been clarified. The aim of this study was to examine the clinical characteristics of the disease.MethodsA retrospective analysis was undertaken of the literature on dabigatran-induced oesophagitis in Chinese and English from 2008 onwards.ResultsThere were 20 men (74.07%) and seven women (25.93%) in the study; their median age was 75 years (range 37–90). The main clinical symptoms were dysphagia (42.31%), odynophagia (26.92%), retrosternal pain (23.08%) and heartburn (23.08%). Endoscopy mainly showed sloughing mucosal casts (14 cases, 56%), ulcers (8 cases, 32%) and erosion (6 cases, 24%). The main injury sites were the mid to lower oesophagus (32%) and the mid oesophagus (32%). Withdrawal of dabigatran or giving the correct medication regimen resulted in rapid recovery of clinical symptoms from 1 day in some patients and up to 4 weeks, and mucosal recovery (2–5 weeks) in a median time of 3 weeks (range 0.29–48) in all patients.ConclusionsOesophagitis is a rare complication of dabigatran with a good prognosis. Patients should be given proper medication instructions to prevent the occurrence of dabigatran-induced oesophagitis.
Details
- Language :
- English
- ISSN :
- 20479956 and 20479964
- Volume :
- 30
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- European Journal of Hospital Pharmacy : Science and Practice
- Publication Type :
- Periodical
- Accession number :
- ejs62572128
- Full Text :
- https://doi.org/10.1136/ejhpharm-2021-002889