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Orthogonal engineering of synthetic T cell states to enhance cancer immunotherapy
- Source :
- Nature Immunology; 20230101, Issue: Preprints p1-3, 3p
- Publication Year :
- 2023
-
Abstract
- Orthogonal engineering of adoptively transferred CD8+T cells to co-express two cytokines — an IL-2Rβ/γ-biased IL-2 variant and the proinflammatory alarmin IL-33 — induces an exhaustion-resistant synthetic cell state with potent anti-tumor efficacy in the absence of host pre-conditioning.
Details
- Language :
- English
- ISSN :
- 15292908 and 15292916
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Nature Immunology
- Publication Type :
- Periodical
- Accession number :
- ejs62873043
- Full Text :
- https://doi.org/10.1038/s41590-023-01470-9