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A noncanonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML
- Source :
- Blood; July 2023, Vol. 142 Issue: 1 p90-105, 16p
- Publication Year :
- 2023
-
Abstract
- •The RNase H–like superfamily member PIWIL4 is required for leukemic stem cell function but dispensable for human hematopoietic stem cells.•PIWIL4 prevents R-loop accumulation, DNA damage, replication stress, and activation of the ATR pathway in AML cells.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Volume :
- 142
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs62987481
- Full Text :
- https://doi.org/10.1182/blood.2022018651