Neonatal Outcomes for Women at Risk of Preterm Delivery Given Half Dose Versus Full Dose of Antenatal Betamethasone: A Randomized, Multicenter, Double-blind, Placebo-controlled, Noninferiority Trial

Authors :: Schmitz, T.
Doret-Dion, M.
Sentilhes, L.
Parant, O.
Claris, O.
Renesme, L.
Abbal, J.
Girault, A.
Torchin, H.
Houllier, M.
Le Saché, N.
Vivanti, A.J.
De Luca, D.
Winer, N.
Flamant, C.
Thuillier, C.
Boileau, P.
Blanc, J.
Brevaut, V.
Bouet, P.E.
Gascoin, G.
Beucher, G.
Datin-Dorriere, V.
Bounan, S.
Bolot, P.
Poncelet, C.
Alberti, C.
Ursino, M.
Aupiais, C.
Baud, O.
Source :: Obstetric Anesthesia Digest; June 2023, Vol. 43 Issue: 2 p84-85, 2p
Publication Year :: 2023
Abstract: (Lancet.2022;400:592–604)Antenatal corticosteroids are recommended worldwide to help premature fetus lung maturity. However, the current recommended dose may be too high, based on some neurological, mental, and behavioral side effects. This study compared a half-dose (12 mg) of antenatal betamethasone to the typical full dose (24 mg) to determine if a half-dose can be as effective as a full dose, as well as to ultimately determine if a half-dose should be recommended in order to lessen side effects.

Full Text Access

Tools