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Limited plasticity of monocyte fate and function associated with epigenetic scripting at the level of progenitors

Authors :
Rhee, Catherine
Scadden, Elizabeth W.
Wong, Lai Ping
Schiroli, Giulia
Mazzola, Michael C.
Chea, Phillip L.
Kato, Hiroki
Hoyer, Friedrich F.
Mistry, Meeta
Lee, Bum-Kyu
Kim, Jonghwan
Nahrendorf, Matthias
Mansour, Michael K.
Sykes, David B.
Sadreyev, Ruslan I.
Scadden, David T.
Source :
Blood; August 2023, Vol. 142 Issue: 7 p658-674, 17p
Publication Year :
2023

Abstract

•Four functional subsets of monocytes were identified by tracking myeloid progenitor clonal descendants.•Interconversion between monocyte subsets is infrequent even with in vivo stress.

Details

Language :
English
ISSN :
00064971 and 15280020
Volume :
142
Issue :
7
Database :
Supplemental Index
Journal :
Blood
Publication Type :
Periodical
Accession number :
ejs63231348
Full Text :
https://doi.org/10.1182/blood.2023020257