Oxide-supported metal catalysts for anaerobic NAD+regeneration with concurrent hydrogen production

We report SiO2-supported monometallic Pt, Pd, Au, Ni, Cu and Co catalysts for proton-driven NAD+regeneration, co-producing H2. All metals are fully selective to NAD+where the order of turnover frequencies (Pt > Pd > Cu > Au, Ni and Co) coincides with those otherwise observed in electrochemical hydrogen evolution reactions. This has revealed that NADH is capable of converting the metal sites into a “cathode” without an external potential and the NADH to NAD+reaction involves transferring electron and hydrogen atom separately. Electron-deficient Ptδ+(on CeO2) enhances TOF and the heterogeneous Pt/CeO2catalyst is recyclable without losing any activity/selectivity.