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Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial

Authors :
Garvey, W Timothy
Frias, Juan P
Jastreboff, Ania M
le Roux, Carel W
Sattar, Naveed
Aizenberg, Diego
Mao, Huzhang
Zhang, Shuyu
Ahmad, Nadia N
Bunck, Mathijs C
Benabbad, Imane
Zhang, Xiaotian M
Abalos, Franklin H.
Manghi, Federico C.P.
Zaidman, Cesar J.
Vico, Marisa L.
Aizenberg, Diego
Costanzo, Pablo R.
Serra, Leonardo P.
MacKinnon, Ignacio J.
Hissa, Miguel N.
Vidotti, Maria H.
Kerr Saraiva, Jose F.
Alves, Breno B.
Franco, Denise R.
Moratto, Otavio
Murthy, Sreenivasa
Goyal, Ghanshyam
Yamasaki, Yoshimitsu
Sato, Nobuyuki
Inoue, Satoshi
Asakura, Taro
Shestakova, Marina
Khaykina, Elena
Troshina, Ekaterina
Vorokhobina, Natalia
Ametov, Alexander
Tu, Shih-Te
Yang, Chwen-Yi
Lee, I-Te
Huang, Chien-Ning
Ou, Horng-Yih
Freeman, George
Machineni, Sriram
Klein, Klara
Sultan, Senan
Parsa, Alan
Otero-Martinez, Juan
Gonzalez, Alex
Bhargava, Anuj
Brian, Susan
Ince, Carlos
Plantholt, Stephen
Cole, Jeremy
Lacour, Audrey
Vega, Damaris
de Souza, Jose
Rohlf, Jane L.
St. John, Roy C.
Horowitz, Barry
Audish, Hanid
Galindo, Rodolfo
Umpiperrez, Guillermo
Ard, Jamy
Curtis, Brian
Garvey, William T.
Fraser, Neil J.
Mandry, Jose
Mohseni, Rizwana
Mayfield, Ronald
Powell, Talessa
Vance, Carl
Ong, Stephen
Lewy-Alterbaum, Ana L.
Murray, Alexander
Al-Karadsheh, Amer
Yacoub, Tamer
Roberts, Kevin
Fried, David L.
Rosenstock, Julio
Pulla, Bharathi
Bode, Bruce
Frias, Juan
Klaff, Leslie
Brazg, Ronald
Van, Joanna
Tan, Anjanette
Briskin, Toby
Rhee, Margaret
Chaicha-Brom, Tira
Hartley, Paul A.
Nunez, Lazaro
Cortes-Maisonet, Gregorio
Soucie, Gary
Hsia, Stanley
Jones, Thomas
Source :
The Lancet; August 2023, Vol. 402 Issue: 10402 p613-626, 14p
Publication Year :
2023

Abstract

Weight reduction is essential for improving health outcomes in people with obesity and type 2 diabetes. We assessed the efficacy and safety of tirzepatide, a glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, versus placebo, for weight management in people living with obesity and type 2 diabetes.

Details

Language :
English
ISSN :
01406736 and 1474547X
Volume :
402
Issue :
10402
Database :
Supplemental Index
Journal :
The Lancet
Publication Type :
Periodical
Accession number :
ejs63408880
Full Text :
https://doi.org/10.1016/S0140-6736(23)01200-X