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Treatment with an ileal bile acid transporter inhibitor in patients with TJP2 deficiency

Authors :
Di Giorgio, Angelo
Sciveres, Marco
Fuoti, Maurizio
Sonzogni, Aurelio
Mandato, Claudia
D'Antiga, Lorenzo
Source :
Clinics and Research in Hepatology and Gastroenterology; October 2023, Vol. 47 Issue: 8
Publication Year :
2023

Abstract

•Children with PFIC-4 may develop cholestasis characterized by high serum bile acids and pruritus.•Odevixibat is effective to reduce serum bile acids levels and treat pruritus in children with PFIC-4.•Odevixibat is safe and well tolerated.

Details

Language :
English
ISSN :
22107401
Volume :
47
Issue :
8
Database :
Supplemental Index
Journal :
Clinics and Research in Hepatology and Gastroenterology
Publication Type :
Periodical
Accession number :
ejs63631412
Full Text :
https://doi.org/10.1016/j.clinre.2023.102185