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Sézary syndrome originates from heavily mutated hematopoietic progenitors

Authors :
Harro, Carly M.
Sprenger, Kimberly B.
Chaurio, Ricardo A.
Powers, John J.
Innamarato, Patrick
Anadon, Carmen M.
Zhang, Yumeng
Biswas, Subir
Mandal, Gunjan
Mine, Jessica A.
Cortina, Carla
Nagy, Mate Z.
Martin, Alexandra L.
Handley, Katelyn F.
Borjas, Gustavo J.
Chen, Pei-Ling
Pinilla-Ibarz, Javier
Sokol, Lubomir
Yu, Xiaoqing
Conejo-Garcia, Jose R.
Source :
Blood Advances; September 2023, Vol. 7 Issue: 18 p5586-5602, 17p
Publication Year :
2023

Abstract

•CTCL cells arise from mutated hematopoietic stem cells after thymic egression.•Clonally enriched CTCL cells carry these progenitor mutations.

Details

Language :
English
ISSN :
24739529 and 24739537
Volume :
7
Issue :
18
Database :
Supplemental Index
Journal :
Blood Advances
Publication Type :
Periodical
Accession number :
ejs63694791
Full Text :
https://doi.org/10.1182/bloodadvances.2022008562