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Optimization of M3Antagonist–PDE4 Inhibitor (MAPI) Dual Pharmacology Molecules for the Treatment of COPD
- Source :
- Journal of Medicinal Chemistry; 20230101, Issue: Preprints
- Publication Year :
- 2023
-
Abstract
- Aiming at the inhaled treatment of pulmonary diseases, the optimization process of the previously reported MAPI compound 92ais herein described. The project was focused on overcoming the chemical stability issue and achieving a balanced bronchodilator/anti-inflammatory profile in rats in order to be confident in a clinical effect without having to overdose at one of the biological targets. The chemical strategy was based on fine-tuning of the substitution pattern in the muscarinic and PDE4 structural portions of the dual pharmacology compounds, also making use of the analysis of a proprietary crystal structure in the PDE4 catalytic site. Compound 10fwas identified as a chemically stable, potent, and in vivobalanced MAPI lead compound, as assessed in bronchoconstriction and inflammation assays in rats after intratracheal administration. After the in-depth investigation of the pharmacological and solid-state profile, 10fproved to be safe and suitable for development.
Details
- Language :
- English
- ISSN :
- 00222623 and 15204804
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Journal of Medicinal Chemistry
- Publication Type :
- Periodical
- Accession number :
- ejs63724512
- Full Text :
- https://doi.org/10.1021/acs.jmedchem.3c01012