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Suzuki–Miyaura Type Regioselective C–H Arylation of Aromatic Aldehydes by a Transient Directing Strategy
- Source :
- Organic Letters; September 2023, Vol. 25 Issue: 37 p6823-6829, 7p
- Publication Year :
- 2023
-
Abstract
- Herein, we disclose a common approach for palladium-catalyzed direct coupling of the ortho-C–H bond of aromatic aldehydes with various organoboronic reagents by a transient directing strategy. In contrast to widely used cross-coupling reactions of C–H bonds with aryl halides, which generally need silver salt as a halide removal reagent, the method which used BQ/TFA as weak oxidation system for the PdII/Pd0redox cycle is cost-effective, ecofriendly, and more aligned with green catalysis. This broadly applicable method opens up a new and efficient Suzuki–Miyaura coupling route for the direct formation of carbon–carbon bonds by C–H bond activation.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 25
- Issue :
- 37
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs63870099
- Full Text :
- https://doi.org/10.1021/acs.orglett.3c02307