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S-(1,3-Dioxoisoindolin-2-yl)O,O-diethyl phosphorothioate (SDDP): A practical electrophilic reagent for the phosphorothiolation of electron-rich compounds
- Source :
- Chinese Chemical Letters; 20230101, Issue: Preprints
- Publication Year :
- 2023
-
Abstract
- An efficient synthesis of the electrophilic reagent, S-(1,3-dioxoisoindolin-2-yl)O,O-diethyl phosphorothioate (SDDP) is described. Moreover, the synthetic applications of SDDP wherein the transfer of the SP(O)(OEt)2moiety occurs were investigated. In this manner, SDDP underwent facile SP(O)(OEt)2transfer with electron-rich substrates such as ketones, indoles, and thiols to form α-phosphorothiolated ketones, 3-phosphorothiolated indoles and S-phosphorothiolated thioethers, respectively.
Details
- Language :
- English
- ISSN :
- 10018417
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Chinese Chemical Letters
- Publication Type :
- Periodical
- Accession number :
- ejs63910598
- Full Text :
- https://doi.org/10.1016/j.cclet.2023.109076