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RNA epigenetic modifications in ovarian cancer: The changes, chances, and challenges
- Source :
- Wiley Interdisciplinary Reviews: RNA; September 2023, Vol. 14 Issue: 5
- Publication Year :
- 2023
-
Abstract
- Ovarian cancer (OC) is the most common female cancer worldwide. Patients with OC have high mortality because of its complex and poorly understood pathogenesis. RNA epigenetic modifications, such as m6A, m1A, and m5C, are closely associated with the occurrence and development of OC. RNA modifications can affect the stability of mRNA transcripts, nuclear export of RNAs, translation efficiency, and decoding accuracy. However, there are few overviews that summarize the link between m6A RNA modification and OC. Here, we discuss the molecular and cellular functions of different RNA modifications and how their regulation contributes to the pathogenesis of OC. By improving our understanding of the role of RNA modifications in the etiology of OC, we provide new perspectives for their use in OC diagnosis and treatment. This article is categorized under:RNA Processing > RNA Editing and ModificationRNA in Disease and Development > RNA in Disease The important roles of RNA modifications in ovarian cancer.
Details
- Language :
- English
- ISSN :
- 17577004 and 17577012
- Volume :
- 14
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Wiley Interdisciplinary Reviews: RNA
- Publication Type :
- Periodical
- Accession number :
- ejs63955460
- Full Text :
- https://doi.org/10.1002/wrna.1784