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Neuropsychiatric manifestations and sleep disturbances with dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: a secondary analysis of the ODYSSEY trial
Authors :
Turkova, Anna White, Ellen Kekitiinwa, Adeodata R Mumbiro, Vivian Kaudha, Elizabeth Liberty, Afaaf Ahimbisibwe, Grace Miriam Moloantoa, Tumelo Srirompotong, Ussanee Mosia, Nozibusiso Rejoice Puthanakit, Thanyawee Kobbe, Robin Fortuny, Clàudia Kataike, Hajira Bbuye, Dickson Na-Rajsima, Sathaporn Coelho, Alexandra Lugemwa, Abbas Bwakura-Dangarembizi, Mutsa F Klein, Nigel Mujuru, Hilda A Kityo, Cissy Cotton, Mark F Ferrand, Rashida A Giaquinto, Carlo Rojo, Pablo Violari, Avy Gibb, Diana M Ford, Deborah Mehar (nee Abdulla), Amina Farhana Abraham, Pattamukkil Abrams, Elaine Acero, Judith Agaba, Gerald Muzorah Ahimbisibwe, Grace Ainebyoona, Barbara Akobye, Winnie Akhalwaya, Yasmeen Akoojee, Nazim Ali, Shabinah S. Amuge, Pauline Andrea, Catherine Muñoz Fernandez, Maria Angeles Ankunda, Rogers Rutebarika, Diana Antonia Anugulruengkitt, Suvaporn Apollo, Tsitsi Archary, Moherndran Arendze, Ronelle Ategeka, Juliet Atim, Eunice Atwine, Lorna Babiker, Abdel Babirye, Sarah Babu, Enock Bagirigomwa, Edward Baita, Angella Balamusani, David Baliram, Patsy Baliruno, David Ball, Colin Balwa, Henry Bamford, Alasdair Bandi, Srini Barker, Dominique Barlow-Mosha, Linda Bbuye, Dickson Begum, Shazia Behuhuma, Osee Bernays, Sarah Besigye, Rogers Bester, Maria Bhiri, Joyline Bilardi, Davide Bird, Kristien Bollen, Pauline Borg, Chiara Borges Da Silva, Anne-Marie Brown, Jackie Bruno, Elena Bunupuradah, Torsak Burger, David Buthelezi, Nomzamo Bwakura-Dangarembizi, Mutsa Byaruhanga, Africanus Calvert, Joanna Casey, Petronelle Cassim, Haseena Cebekhulu, Sphiwee Chailert, Sanuphong Chalermpantmetagul, Suwalai Chamjamrat, Wanna Chan, Man Chandiwana, Precious Chankun, Thannapat Chanthaburanun, Sararut Chanto, Nuttawut Chidziva, Ennie Chikowore, Minenhle Chimanzi, Joy Chinwong, Dujrudee Chitongo, Stuart Chitsamatanga, Moses Choga, Joshua Chutima, Duangrat Clayden, Polly Coelho, Alexandra Colbers, Angela Compagnucci, Alexandra Constança Mendes, Ana Conway, Magda Cotton, Mark F Crawley, Jane Cressey, Tim R Crisp, Jacky Matos, Ana Cristina Dadan, Sumaya Daglish, Jacqui Danaviah, Siva Daniel, Tseleng De Rossi, Anita Denjanta, Sukanda Dobbels, Els Dowie, Maria Dube, Prosper Dube, Benedictor Dudakia, Nimisha Elwana, Alice Epalza, Cristina Eram, David Erasmus, Juan Erim, Peter Escosa Garcia, Luis Essack, Zaakirah Estepa, Carolina Etima, Monica Fernandes, Alexandre Fernandez, Maite Fitzgerald, Felicity Flynn, Jacquie Ford, Deborah Fortuny Guasch, Claudia Foster, Caroline Fourie, George Fourie, Yolandie Foxall, Sophie Frank, Derusha Gandhi, Kate Garcia, India Gartner, Kathleen Gasa, Joshua Gasa, Gugu Giaquinto, Carlo Gibb, Diana M Gomez Rico, Coral Gomez-Pena, Daniel Gondo, Secrecy Goodman, Anna Gorreti Nakalema, Maria Gozhora, Winnie Greetanukroh, Pisut Gregorio Maranon, Biobanco Grossele, Tiziana Gwande, Shamiso Gwaze, Tapiwa Gwenzi, Tsitsi Hakim, James Hakiza, Emmanuel Kaka, Abdul Hamid Harley, Ashley Isaacs, Mornay Isabirye, Richard Ishemunyoro, Wilber Jacobs, Tom Jafta, Lungile Jamil, Nasir Janse van Rensburg, Anita Janse Jeaven, Vinesh Mellado Peña, Maria José Jourdain, Gonzague Juliet, Katabalwa Jumpimai, Thidarat Junkaew, Raungwit Jupimai, Thidarat Kaahwa, Winfred Kabasonga, Mildred Kaboggoza, Olivia Kadhuba, Rose Jacqueline Kaewbundit, Ampika Kaewmamueng, Kanyanee Kafufu, Bosco Kakayi, Brenda Kamboua, Phakamas Kanjanavanit, Suparat Kasangaki, Gladys Kasipong, Naruporn Kasozi, Miriam Kataike, Hajira Katemba, Chrispus Kaudha, Elizabeth Kekane, Nkata Kekitiinwa, Adeodata R Keminyeto, Edridah Khamduang, Woottichai Khamjakkaew, Warunee Khamkon, Jiraporn Khannak, Sasipass Khatngam, Orapin Khayanchoomnoom, Tassawan Khumalo, Busi Khunene, Mirriam Khusuwan, Suwimon Kibalama, Phionah Kibenge, Robinah Kirabira, Anthony Kityo, Cissy M Kiyimba, Lameck Klein, Nigel Klinprung, Soraya Kobbe, Robin Kobusingye, Olivia Kobusungye, Josephine Kongponoi, Areerat Königs, Christoph Koole, Olivier Kouakam, Christelle Krueduangkam, Nitinart Kruenual, Namthip Kunjaroenrut, Nuananong Kyambadde, Raymonds Kyobutungi, Priscilla Kyomuhendo, Flavia Kyomukama, Erinah Lakha, Reshma Langa, Cleopatra Laomanit, Laddawan Lebotsa, Emily Leenasirimakul, Prattana Lekku, Lawrence Lensen, Sarah Leroy, Valériane Li, Jin Liberty, Afaaf Limplertjareanwanich, Juthamas Little, Emma Lugemwa, Abbas Lutalo, Ezra Jimenez, Jose Luis Lyall, Hermione MacDonald, Candice Machache, Gladness Madlala, Penelope Madonsela, Tryphina Maduna, Nomfundo Maena, Joel Mahanontharit, Apicha Makanga, Collin Makola, Candice Makumbi, Shafic Malgraaf, Lucille Mamiane, Angelous Mantkowski, Felicia Mapfumo, Wendy Marques, Laura Mugagga, Agnes Mary Maseko, Lindiwe Masienyane, Tshepiso Mathiba, Ruth Matimba, Farai Mawlana, Sajeeda Mayanja, Emmanuel Mayat, Fatima Mbabazi, Ritah Mbadaliga, Nokuthula Mbasani, Faith McClaughlin, Kathleen McIlleron, Helen Meethaisong, Watchara Mendez Garcia, Patricia Miwanda, Annet Miranda, Carlota Mkhize, Siphiwe Mmolawa, Kgosimang Mngqibisa, Rosie Mohamed, Fatima Moloantoa, Tumelo Monametsi, Maletsatsi Montero, Samuel Moore, Cecilia L Mosia, Rejoice Moyo, Columbus Mthethwa, Mumsy Mudzingwa, Shepherd Mudzviti, Tawona Mujuru, Hilda Mujyambere, Emmanuel Mukanganiki, Trust Mukisa Williams, Cynthia Mulder, Mark Mulima, Disan Mulindwa, Alice Mumbiro, Vivian Mupambireyi, Zivai Murciano Cabeza, Alba Murungi, Herbert Murungu, Dorothy Musarurwa, Sandra Musiime, Victor Musiime, Alex V Musisi, Maria Musoke, Philippa Musoke Nakirya, Barbara Musoro, Godfrey Musumba, Sharif Mustafa, Sobia Mutsai, Shirley Mwesigwa Rubondo, Phyllis Naabalamba, Mariam Nagawa, Immaculate Naidoo, Allemah Nakabuye, Shamim Nakabuye, Sarah Nakalanzi, Sarah Nalubwama, Justine Nalugo, Annet Nalusiba, Stella Namajja, Clementine Namanda, Sylvia Namayanja, Paula Nambi, Esther Namuddu, Rachael Kikabi Namukwaya, Stella Namuli, Florence Namusanje, Josephine Namwanje, Rosemary Nanan-kanjee, Anusha Nanduudu, Annet Nankunda, Charity Baddokwaya, Joanita Nankya Nannungi, Maria Nansamba, Winnie Nanthapisal, Kesdao Nanyonjo, Juliet Na-Rajsima, Sathaporn Nasaazi, Claire Nascimento, Helena Nastouli, Eleni Songtaweesin, Wipaporn Natalie Nathoo, Kusum Natuhurira, Ian Nazzinda, Rashidah Ncgaba, Thabisa Ndigendawani, Milly Ndlovu, Makhosonke Nentsa, Georgina Ngampiyaskul, Chaiwat Ngcobo, Ntombenhle Ngo Giang Huong, Nicole Ngwaru, Pia Nhema, Ruth Ninsiima, Emily Ninsiima, Gloria Nkalo Phiri, Misheck Noguera Julian, Antoni Nolan, Monica Noppakaorattanamanee, Thornthun Nsibuka Kisekka, Muzamil Nsirim, Eniola Nundlal, Rashina Nunes, Rosita Nyantsa, Lungile Nyati, Mandisa O'Riordan, Sean Ocitti Labeja, Paul Odoch, Denis Oguntimehin, Rachel Ojok, Martin Onen, Geoffrey Orange, Wilma Ounchanum, Pradthana Ouma, Benson Padrao, Andreia Pako, Deborah Parker, Anna Pasko-Szcech, Malgorzata Patel, Reena Peongjakta, Rukchanok Petpranee, Turian Phillips, Tasmin Philps, Jackie Picault, Laura Pieterse, Sonja Pinheiro, Helena Pongprapass, Supawadee Pozniak, Anton Prendergast, Andrew Prieto Tato, Luis Puangmalai, Patcharee Puthanakit, Thanyawee Rakgokong, Modiehi Ramos, Helena Ramsagar, Nastassja Rau, Cornelius Riault, Yoann Rojo Conejo, Pablo Clark, Basiimwa Roy Rubanga, Eddie Rubinga, Baker Ruklao, Chutima Runarassamee, Pattira Rutebarika, Diana Antonia Saenjum, Chalermpong Saewtrakool, Chayakorn Saidi, Yacine Sainz Costa, Talia Saisaengjan, Chutima Sakwa, Rebecca Sarfati, Tatiana Sbisi, Noshalaza Scheppers, Dihedile Schultze-Strasser, Stephan Schulze-Sturm, Ulf Scott, Karen Seeley, Janet Serunjogi, Robert Sewnarain, Leora Shakeshaft, Clare Sidhoo, Subashinie Shibemba, Mercy Shingadia, Delane Singh, Sheleika Sirirungsi, Wasna Sithebe, Sibongile Smit, Theresa Smith, Kurt Smuts, Marlize Spyer, Moira Sripaoraya, Worathip Srirompotong, Ussanee Srisuk, Warunee Ssenyonga, Mark Sudsaard, Patamawadee Sukrakanchana, Praornsuda Tearsansern, Pathanee Teixeira, Carla Than-in-at, Kanchana Thapwai, Thitiwat Thaweesombat, Yupawan Thewsoongnoen, Jutarat Thiébaut, Rodolphe Thomason, Margaret Thrasyvoulou, Laura Thungkham, Khanungnit Tikabibamu, Judith Tinago, Gloria Trairat, Ketmookda Tudor-Williams, Gareth Tukamushaba, Mercy Tukwasibwe, Deogratiuos Tumusiime, Julius Tuna, Joana Turkova, Anna Turner, Rebecca Udomvised, Arttasid Vadee, Aasia Van Huyssteen, Hesti Van Looy, Nadine Variava, Ebrahim Vaughan-Gordon, Yvonne Vecchia, Giulio Violari, Avy Vowden, Richard Waalewijn, Hylke Wampamba, Rebecca Welch, Steve Weller, Ian Weza, Sibusisiwe White, Ellen White, Ian Widuch, Kaja Wilkes, Helen Wimonklang, Sookpanee Wynne, Ben Yingyong, Pacharaporn Nakawungu, Zaam Zinda Zuidewind, Peter
Source :
The Lancet Child & Adolescent Health; October 2023, Vol. 7 Issue: 10 p718-727, 10p
Publication Year :
2023
Abstract
Cohort studies in adults with HIV showed that dolutegravir was associated with neuropsychiatric adverse events and sleep problems, yet data are scarce in children and adolescents. We aimed to evaluate neuropsychiatric manifestations in children and adolescents treated with dolutegravir-based treatment versus alternative antiretroviral therapy.
Details
Language :
English
ISSN :
23524642 and 23524650
Volume :
7
Issue :
10
Database :
Supplemental Index
Journal :
The Lancet Child & Adolescent Health
Publication Type :
Periodical
Accession number :
ejs64010520
Full Text :
https://doi.org/10.1016/S2352-4642(23)00164-5