Pathogen‐Targeting Bimetallic Nanozymes as Ultrasonic‐Augmented ROS Generator against Multidrug Resistant Bacterial Infection

Clinical treatment of multidrug resistant (MDR) pathogens‐induced infection is emerging as a growing challenge in global public health due to the limited selection of clinically available antibiotics. Nanozymes as artificial enzymes that mimicked natural enzyme‐like activities, are received great attention for combating MDR pathogens. However, the relatively deficient catalytic activity in the infectious microenvironment and inability to precisely targeting pathogen restrains their clinical anti‐MDR applications. Here, pathogen‐targeting bimetallic BiPt nanozymes for nanocatalytic therapy against MDR pathogen are reported. Benefiting from electronic coordination effect, BiPt nanozymes exhibit dual‐enzymatic activities, including peroxidase‐mimic and oxidase‐mimic activities. Moreover, the catalytic efficiency can be efficiently increased 300‐fold by ultrasound under inflammatory microenvironment. Notably, BiPt nanozyme is further cloaked with a platelet‐bacteria hybrid membrane (BiPt@HMVs), thus presenting excellent homing effect to infectious sites and precise homologous targeting to pathogen. By integrating accurate targeting with highly efficient catalytic, BiPt@HMVs can eliminate carbapenem‐resistant Enterobacteralesand methicillin‐resistant Staphylococcus aureusin osteomyelitis rats model, muscle‐infected mice model, and pneumonia mice model. The work provides an alternative strategy based on nanozymes for clinically addressing MDR bacteria‐induced infections. The biomimetic BiPt nanozymes can precisely deliver to the infectious sites and adherent to pathogen, then exhibit improved peroxidase‐mimic activity and oxidase‐mimic activity by ultrasound irradiation, finally addressing multidrug resistant bacteria infection.