Platelet‐Membrane‐Coated Polydopamine Nanoparticles for Neuroprotection by Reducing Oxidative Stress and Repairing Damaged Vessels in Intracerebral Hemorrhage

Intracerebral hemorrhage (ICH) has a high morbidity and mortality rate. Excessive reactive oxygen species (ROS) caused by primary and second brain injury can induce neuron death and inhibit neurological functional recovery after ICH. Therefore, exploring an effective way to noninvasively target hemorrhage sites to scavenge ROS is urgently needed. Inspired by the biological function of platelets to target injury vessel and repair injury blood vessels, platelet‐membrane‐modified polydopamine (Menp@PLT) nanoparticles are developed with targeting to hemorrhage sites of ICH. Results demonstrate that Menp@PLT nanoparticles can effectively achieve targeting to the location of intracranial hematoma. Furthermore, Menp@PLT with excellent anti‐ROS properties can scavenge ROS and improve neuroinflammation microenvironment of ICH. In addition, Menp@PLT may play a role in decreasing hemorrhage volume by repairing injury blood vessels. Combining platelet membrane and anti‐ROS nanoparticles for targeting brain hemorrhage sites provide a promising strategy for efficiently treating ICH. Platelet‐membrane‐coated polydopamine nanoparticles (Menp@PLT) are fabricated to improve the targetability and accumulation in the hemorrhage sites and further stop bleeding. In the meanwhile, Menp@PLT can protect damaged neurons by anti‐reactive oxygen species and anti‐reactive nitrogen species, improving the inflammatory microenvironment.