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Antifungal efficacy of imidazo[1,2-a]pyrazine-based thiosemicarbazones and thiazolidinediones against Sporothrixspecies
- Source :
- Future Microbiology; October 2023, Vol. 18 Issue: 17 p1225-1233, 9p
- Publication Year :
- 2023
-
Abstract
- Aim:To evaluate antifungal potential of 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hybrids based on thiosemicarbazones and thiazolidinediones against pathogenic Sporothrixspecies. Methods:Antifungal activity of nine compounds were assessed by broth microdilution. Interactions between active compounds and itraconazole were evaluated by the checkerboard assay using non-wild-type isolates. Cytotoxicity of the compounds was determined. Results:Four C-3 substituted analogs showed antifungal activity, unrelated to thiosemicarbazone or thiazolidinedione functions. Synergistic interactions between the four compounds and itraconazole, and low toxicity on mouse fibroblast cells were observed. Activity of 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hybrids against Sporothrixdepended on the substitution on the imidazopyrazine ring. Conclusion:Antifungal potential, overcoming itraconazole resistance and low toxicity indicate the possible use of that series of compounds in a therapeutic alternative for treatment of sporotrichosis.
Details
- Language :
- English
- ISSN :
- 17460913 and 17460921
- Volume :
- 18
- Issue :
- 17
- Database :
- Supplemental Index
- Journal :
- Future Microbiology
- Publication Type :
- Periodical
- Accession number :
- ejs64325803
- Full Text :
- https://doi.org/10.2217/fmb-2023-0044