Skip to search
Skip to main content
Back to Search
Start Over
A multi-platform approach to identify a blood-based host protein signature for distinguishing between bacterial and viral infections in febrile children (PERFORM): a multi-cohort machine learning study
Authors :
Jackson, Heather R Zandstra, Judith Menikou, Stephanie Hamilton, Melissa Shea McArdle, Andrew J Fischer, Roman Thorne, Adam M Huang, Honglei Tanck, Michael W Jansen, Machiel H De, Tisham Agyeman, Philipp K A Von Both, Ulrich Carrol, Enitan D Emonts, Marieke Eleftheriou, Irini Van der Flier, Michiel Fink, Colin Gloerich, Jolein De Groot, Ronald Moll, Henriette A Pokorn, Marko Pollard, Andrew J Schlapbach, Luregn J Tsolia, Maria N Usuf, Effua Wright, Victoria J Yeung, Shunmay Zavadska, Dace Zenz, Werner Coin, Lachlan J M Casals-Pascual, Climent Cunnington, Aubrey J Martinon-Torres, Federico Herberg, Jethro A de Jonge, Marien I Levin, Michael Kuijpers, Taco W Kaforou, Myrsini Jackson, Heather Ruth Zandstra, Judith Menikou, Stephanie Hamilton, Shea McArdle, Andrew J De, Tisham Agyeman, Philipp K A Von Both, Ulrich Carrol, Enitan D Emonts, Marieke Eleftheriou, Irini Van der Flier, Michiel Fink, Colin De Groot, Ronald Moll, Henriette A Pokorn, Marko Pollard, Andrew Schlapbach, Luregn J Tsolia, Maria Usuf, Effua Wright, Victoria Yeung, Shunmay Zavadska, Dace Zenz, Werner Coin, Lachlan JM Cunnington, Aubrey J Martinon-Torres, Federico Herberg, Jethro De Jonge, Marien I Levin, Michael Kuijpers, Taco Kaforou, Myrsini Abdulla, Amina Aebi, Christoph Agbeko, Rachel Ali, Ladan Alkema, Wynand Allen, Karen Anderson, Suzanne Ansari, Imran Arif, Tasnim Avramoska, Tanja Baas, Bryan Bahovec, Natalija Balode, Anda Bãrdzdina, Arta Barendregt, A M Barral-Arca, Ruth Bath, David Bauchinger, Sebastian Baumard, Lucas Baumgart, Hinrich Baxter, Frances Bell, Kathryn Bell, Ashley Bello, Xabier Bellos, Evangelos Benesch, Martin Bennet, Joshua Berger, Christoph Bernhard-Stirnemann, Sara Bibi, Sagida Bidlingmaier, Christoph Binder, Alexander Binder, Vera Blackmore, Jennifer Bojang, Kalifa Borensztajn, Dorine M Brengel-Pesce, Karen Broderick, Claire Buschbeck, Judith Calvo-Bado, Leonides Carnota, Sandra Carter, Michael J Castro, María Barreiro Cebey-López, Miriam Ceesay, Samba Ceolotto, Astrid Chan, Adora Cocklin, Elizabeth Collings, Kalvin Crulley, Stephen Curras-Tuala, María José D'alessandro, Umberto D'Souza, Giselle Danhauser, Katharina Darboe, Saffiatou Darnell, Sarah De Haan, L De Vries, Gabriella Deksne, Dãrta Devine, Kirsty Dewez, Juan Emmanuel Dik, W Dudley, Julia Eber, Ernst Fabian, Daniel Farto, Cristina Balo Fernández, Sonia Serén Fidler, Katy Fitchett, Elizabeth Galassini, Rachel Gallisti, Siegfried García, Mirian Ben Gardovska, Dace Geissler, J Gerrits, G P J M Giannoni, Eric Gloerich, Jolein Gómez-Carballa, Alberto González, Fernando Álves Gores, Gunther Grãvele, Dagne Griese, Matthias Grope, Ilze Gurung, Meeru Haas, Nikolaus Habgood-Coote, Dominic Hagedoorn, Nienke N Haidl, Harald Harrison, Rebekah Hauer, Almuthe Heidema, J Heininger, Ulrich Henriet, Stefanie Hibberd, Martin Hoggart, Cllive Hösele, Susanne Hourmat, Sara Hude, Christa Huijnen, Martijn Iglesias, Pilar Leboráns Iglesias, Marisol Vilas Jennings, Rebecca Johnson, Joanne Jongerius, Ilse Jorgensen, Rikke Kahlert, Christian Kandasamy, Rama Kappler, Matthias Keldorfer, Markus Kelly, Dominic F Khanijau, Aakash Kim, Nayoung Kim, Eunjung King, Sharon Kolberg, Laura Kolnik, Mojca Kloosterhuis, Lieke Kohlfürst, Daniela S Kohlmaier, Benno Krenn, Larissa Leigh, Simon Leitner, Manuel Leurent, Baptiste Lim, Emma Lin, Naomi Liu, Ching-Chuan Löffler, Sabine Lurz, Eberhard Mackerness, Christine Maconochie, Ian Mallet, Francois Marmarinos, Antonis Martin, Alex Martin, Mike Martinón Sánchez, José María Martinón-Torres, Nazareth McAlinden, Paul McDonald, Sam McDonell, Anne Meiere, Anija Meierford, Anne Miedema, C J Miners, Alec Mistry, Ravi Mommert, Marine Morris, Sophie Muench, Georg Murdoch, David R Mustafa, Sobia Natalucci, Giancarlo Neeleman, C Newall, Karen Nichols, Samuel Niederer-Loher, Anita Niedrist, Tobias Nijman, Ruud Nokalna, Ieve Nordberg, Gudrun O'Connor, Daniel Obihara, C C Oliver, Zoe Oosthoek, Wilma Ora, Miguel Sadiki Osterman, Veronika Pachot, Alexandre Pajkrt, D Pardo-Seco, Jacobo Pavãre, Jana Paz, Ivonne Pena Paulus, Stéphane Pérez, Belén Mosquera Persand, Salina Pfleger, Andreas Pfurtscheller, Klaus Philipsen, Ria Pickering, Alisa Pierce, Benjamin Pilch, Heidemarie Pischedda, Sara Pölz, Lena Posfay-Barbe, Klara M Powell, Oliver Prunk, Petra Pučuka, Zanda Rajic, Glorija Rashid, Aqeela Redondo-Collazo, Lorenzo Reiter, Karl Relly, Christa Rhodes, Mathew Rial, Jose Gómez Richmond, Vivien Riedel, Thomas Rivero Calle, Irene Roca, Anna Rödl, Siegfried Rodríguez, Lidia Piñeiro Rodríguez-Tenreiro, Carmen Romaine, Sam Rowlands, Emily Rudzate, Aleksandra Sagmeister, Manfred Saidykhan, Momodou Sallas, Antonio Sarr, Isatou Schoen, Carola Schonenberg, D Schweintzger, Nina Secka, Fatou Selecka, Katrīna Shah, Priyen Shen, Ching-Fen Shrestha, Shrijana Skrabl-Baumgartner, Andrea Soon, Joshua Sperl, Matthias Sprenkeler, Evelien Spyridis, Nikos Srovin, Tina Plankar Stampfer, Laura Stevens, Molly Stocker, Martin Strenger, Volker Suárez, Carlos Durán Svile, Dace Syggelou, Kelly Tal, Chantal Tambouratzi, Maria Tavliavini, Emma Thakker, Clare Thomson, Evelyn Throson, Stephen Till, Holger Tramper-Stranders, G A Trasorras, Cristina Serén Trobisch, Andreas Urbãne, Urzula Nora Usman, Mariama Valentine, Lucille Van Aerde, Koen Van den Berg, J M Van den Broek, Bryan Van der Giessen, Ilona Van der Kuip, M Van der Velden, Fabian Van Furth, A M Van Gool, Alain J Van Leur, M van Mierlo, G Vázquez, Sara Ray Vermont, Clementien Vicente, Luisa García Vincek, Katarina Vito, Ortensia Voice, Marie Wallia, Diane Walsh, Ben Wang, Shih-Min Wedderburn, Catherine Willems, Esther Wilson, Clare Wood, Amanda Woodsford, Phil Wyss, Verena Xagorari, Marietta Zachariasse, Joany Zaman, Syed M A Zurl, Christoph Zwerenz, Manuela
Source :
The Lancet Digital Health; November 2023, Vol. 5 Issue: 11 pe774-e785, 12p
Publication Year :
2023
Abstract
Differentiating between self-resolving viral infections and bacterial infections in children who are febrile is a common challenge, causing difficulties in identifying which individuals require antibiotics. Studying the host response to infection can provide useful insights and can lead to the identification of biomarkers of infection with diagnostic potential. This study aimed to identify host protein biomarkers for future development into an accurate, rapid point-of-care test that can distinguish between bacterial and viral infections, by recruiting children presenting to health-care settings with fever or a history of fever in the previous 72 h.
Details
Language :
English
ISSN :
25897500
Volume :
5
Issue :
11
Database :
Supplemental Index
Journal :
The Lancet Digital Health
Publication Type :
Periodical
Accession number :
ejs64337815
Full Text :
https://doi.org/10.1016/S2589-7500(23)00149-8