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Urokinase-type plasminogen activator (uPA) regulates invasion and matrix remodelling in colorectal cancer
- Source :
- Matrix Biology Plus; December 2023, Vol. 19 Issue: 1
- Publication Year :
- 2023
-
Abstract
- •Invasive breast and colorectal cancer cells locally degrade their tumour microenvironment.•Urokinase-type plasminogen activator (uPA) is overexpressed in invasive cancer cells.•Targeting uPA stops matrix degradation.•Targeting uPA limits cancer invasion.•uPA therefore has high potential as a target for mechano-based cancer therapies.
Details
- Language :
- English
- ISSN :
- 25900285
- Volume :
- 19
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Matrix Biology Plus
- Publication Type :
- Periodical
- Accession number :
- ejs64515811
- Full Text :
- https://doi.org/10.1016/j.mbplus.2023.100137