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Formal Synthesis of Ezetimibe Using a Proline-mediated, Asymmetric, Three-component Mannich Reaction
- Source :
- Chemistry Letters; January 2016, Vol. 45 Issue: 1 p30-32, 3p
- Publication Year :
- 2016
-
Abstract
- The formal total synthesis of ezetimibe was accomplished using a proline-mediated, asymmetric, three-component Mannich reaction as the key step. The two stereogenic centers on the ß-lactam skeleton of ezetimibe were controlled by the syn-selective asymmetric Mannich reaction, followed by isomerization.
Details
- Language :
- English
- ISSN :
- 03667022 and 13480715
- Volume :
- 45
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Chemistry Letters
- Publication Type :
- Periodical
- Accession number :
- ejs64657006
- Full Text :
- https://doi.org/10.1246/cl.150916