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Exosomal Vesicles: A Therapeutic Strategy Against Severe Sars-Cov-2 in Multiple Myeloma Patients
- Source :
- Blood; November 2023, Vol. 142 Issue: 1, Number 1 Supplement 1 p7181-7181, 1p
- Publication Year :
- 2023
-
Abstract
- During the early phase of the pandemic, studies revealed that COVID-19 patients with multiple myeloma (MM) had significantly higher hospitalization rates (56%), with 20% requiring critical care and 18% facing an increased risk of mortality. MM patients undergoing anticancer therapy showed a 55% higher risk of mortality when infected with COVID-19. Even in the post-pandemic world, MM patients remain at heightened risk for breakthrough infections and severe SARS-CoV-2 due to their immunocompromised status, necessitating hospitalization. While both active and remission MM patients exhibited worse outcomes than COVID-19 patients without cancer, limited research exists to elucidate the underlying causes. In this study, we aimed to (1) develop a model elucidating the pathogenesis and interplay between MM and severe SARS-CoV-2, and (2) explain the efficacy and therapeutic potential of Exosomal Vesicles (EVs) as an intervention against severe SARS-CoV-2, supported by clinical evidence.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Volume :
- 142
- Issue :
- 1, Number 1 Supplement 1
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs64702117
- Full Text :
- https://doi.org/10.1182/blood-2023-185101