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Predictors of unsustained measurable residual disease negativity in patients with multiple myeloma

Authors :
D’Agostino, Mattia
Bertuglia, Giuseppe
Rota-Scalabrini, Delia
Belotti, Angelo
Morè, Sonia
Corradini, Paolo
Oliva, Stefania
Ledda, Antonio
Grasso, Mariella
Pavone, Vincenzo
Ronconi, Sonia
Vincelli, Iolanda Donatella
Ballanti, Stelvio
Velluti, Cristina
Cellini, Claudia
Gozzetti, Alessandro
Palmas, Angelo D.
Gamberi, Barbara
Mancuso, Katia
Paris, Laura
Zambello, Renato
Petrucci, Maria Teresa
Bruno, Benedetto
Musto, Pellegrino
Gay, Francesca
Source :
Blood; 20230101, Issue: Preprints
Publication Year :
2023

Abstract

•Amp(1q), HRCA ≥2, high CTC levels, and a longer time to reach first MRD negativity are significant predictors of unsustained MRD negativity.•Maintenance treatment with carfilzomib-lenalidomide reduces the risk of unsustained MRD negativity vs lenalidomide alone.

Details

Language :
English
ISSN :
00064971 and 15280020
Issue :
Preprints
Database :
Supplemental Index
Journal :
Blood
Publication Type :
Periodical
Accession number :
ejs64819291
Full Text :
https://doi.org/10.1182/blood.2023022080