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Identification and surveillance of rare relapse-initiating stem cells during complete remission after transplantation

Authors :
Dimitriou, Marios
Mortera-Blanco, Teresa
Tobiasson, Magnus
Mazzi, Stefania
Lehander, Madeleine
Högstrand, Kari
Karimi, Mohsen
Walldin, Gunilla
Jansson, Monika
Vonlanthen, Sofie
Ljungman, Per
Langemeijer, Saskia
Yoshizato, Tetsuichi
Hellström-Lindberg, Eva
Woll, Petter S.
Jacobsen, Sten Eirik W.
Source :
Blood; March 2024, Vol. 143 Issue: 11 p953-966, 14p
Publication Year :
2024

Abstract

•Mutational screening after transplantation identifies rare relapse-initiating stem cells while patients remain in complete remission.•Mutational screening of HSPCs after stem cell transplantation enhances MRD sensitivity ∼100-fold.

Details

Language :
English
ISSN :
00064971 and 15280020
Volume :
143
Issue :
11
Database :
Supplemental Index
Journal :
Blood
Publication Type :
Periodical
Accession number :
ejs64948945
Full Text :
https://doi.org/10.1182/blood.2023022851