Tumor necrosis factor α promotes clonal dominance of KITD816V+cells in mastocytosis: role of survivin and impact on prognosis

Authors :: Greiner, Georg
Witzeneder, Nadine
Klein, Klara
Tangermann, Simone
Kodajova, Petra
Jaeger, Eva
Ratzinger, Franz
Gerner, Marlene C.
Jawhar, Mohamad
Baumgartner, Sigrid
Fruehwirth, Karin
Schmetterer, Klaus G.
Zuber, Johannes
Gleixner, Karoline V.
Mayerhofer, Matthias
Schwarzinger, Ilse
Simonitsch-Klupp, Ingrid
Esterbauer, Harald
Baer, Constance
Walter, Wencke
Meggendorfer, Manja
Strassl, Robert
Haferlach, Torsten
Hartmann, Karin
Kenner, Lukas
Sperr, Wolfgang R.
Reiter, Andreas
Sexl, Veronika
Arock, Michel
Valent, Peter
Hoermann, Gregor
Source :: Blood; March 2024, Vol. 143 Issue: 11 p1006-1017, 12p
Publication Year :: 2024
Abstract: •KITD816V confers resistance to TNF via BIRC5 (survivin) and promotes clonal dominance.•High TNF levels are associated with inferior survival in SM.

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