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Proton FLASH Irradiation Platform for Small Animal Setup at Chang Gung Memorial Hospital
- Source :
- IEEE Transactions on Radiation and Plasma Medical Sciences; January 2024, Vol. 8 Issue: 1 p88-94, 7p
- Publication Year :
- 2024
-
Abstract
- The purpose of this study was to create a platform for conducting small animal proton FLASH irradiation at a research-specific therapy center using an auxiliary proton beam line. A dose monitoring system was implemented to provide real-time irradiation dose and dose rate time structure information, utilizing a transmission ionization chamber (TIC), a plastic scintillator-based beam position monitor, and a poor man faraday cup (PMFC). Both the TIC and PMFC were equipped with a custom-made fast-reading current integral electronics device, allowing for real-time dose monitoring with a resolution of 0.5 ms. Experimental testing showed that the maximum dose that could be delivered to the target in a single pulse of 230-MeV protons was approximately 20 Gy, during a pulse period of 199 ms, at a dose rate of 100 Gy/s. The establishment of a dedicated proton research platform at Chang Gung Memorial Hospital has enabled investigation of the biological effects of FLASH irradiation on small animals. The final setup data serves as a useful reference for both planning future experiments and improving the facility for beam users. This study’s achievement provides a valuable foundation for further research on proton FLASH irradiation, potentially offering new insights into its applications for cancer treatment.
Details
- Language :
- English
- ISSN :
- 24697311 and 24697303
- Volume :
- 8
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- IEEE Transactions on Radiation and Plasma Medical Sciences
- Publication Type :
- Periodical
- Accession number :
- ejs65085115
- Full Text :
- https://doi.org/10.1109/TRPMS.2023.3319954