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Continuous Flow Synthesis of 5-Methyltetrahydrofolate from Folic Acid

Authors :
Zhang, Yu
Xiao, Minghui
Feng, Ranran
Zhang, Hong-Yu
Zhang, Yuecheng
Zhao, Jiquan
Source :
Organic Process Research & Development; 20240101, Issue: Preprints
Publication Year :
2024

Abstract

5-Methyltetrahydrofolate (5-MTHF) is an active form of folic acid (FA) and an essential micronutrient preventing anemia and numerous other adverse health conditions such as cardiovascular disease and cancer. Herein, a continuous flow sequence synthesis of 5-MTHF from FA was developed, involving three elementary steps: catalytic hydrogenation of FA to tetrahydrofolic acid (THFA), methylenation of THFA with formaldehyde, and hydrogenation of the methylenation intermediates to 5-MTHF. This process features an expeditious synthesis of 5-MTHF in an integrated flow platform with water as the sole solvent and without any intermediate purification. The overall yield of this three-step flow process was up to 53.54% in a total residence time of 71.4 min. The separated yield of 5-MTHF reached 49.3%.

Details

Language :
English
ISSN :
10836160 and 1520586X
Issue :
Preprints
Database :
Supplemental Index
Journal :
Organic Process Research & Development
Publication Type :
Periodical
Accession number :
ejs65433417
Full Text :
https://doi.org/10.1021/acs.oprd.3c00323