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Loss of the stress sensor GADD45A promotes stem cell activity and ferroptosis resistance in LGR4/HOXA9-dependent AML
- Source :
- Blood; July 2024, Vol. 144 Issue: 1 p84-98, 15p
- Publication Year :
- 2024
-
Abstract
- •GADD45Aloss has a dual role in promoting DNA damage while upregulating antioxidants to sustain low ROS essential to safeguard self-renewal.•Deletion of GADD45Aenhances leukemia-initiating activity and therapy resistance by suppressing iron and ROS accumulation and ferroptosis.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Volume :
- 144
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs66005449
- Full Text :
- https://doi.org/10.1182/blood.2024024072