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Hydroxychloroquine inhibits hemolysis-induced arterial thrombosis ex vivoand improves lung perfusion in hemin-treated mice

Authors :
Bourne, Joshua H.
Perrella, Gina
El-Awaisi, Juma
Terry, Lauren V.
Tinkova, Veronika
Hogg, Rebecca L.
Gant, Poppy
Grygielska, Beata
Kalia, Neena
Kavanagh, Dean
Brill, Alexander
Dimitrov, Jordan D.
Watson, Steve P.
Rayes, Julie
Source :
Journal of Thrombosis and Haemostasis; July 2024, Vol. 22 Issue: 7 p2018-2026, 9p
Publication Year :
2024

Abstract

Free labile hemin acts as a damage-associated molecular pattern during acute and chronic hemolysis and muscle injury, supporting platelet activation and thrombosis.

Details

Language :
English
ISSN :
15387933 and 15387836
Volume :
22
Issue :
7
Database :
Supplemental Index
Journal :
Journal of Thrombosis and Haemostasis
Publication Type :
Periodical
Accession number :
ejs66157013
Full Text :
https://doi.org/10.1016/j.jtha.2024.04.008