1,25(OH)2D3inhibits pancreatic stellate cells activation and promotes insulin secretion in T2DM

PSCs activation leads to islet fibrosis in T2DM mice.TGF- β, IL-1 β, TNF-α, ROS induce PSCs activation, thereby inhibiting MIN6 cell proliferation and function.1,25(OH)2D3inhibits PSCs activation by downregulating the expression of factors such as TGF-β, protecting β cell function.