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High efficacy of CD19 CAR T-cells in patients with transformed Waldenström macroglobulinemia.

Authors :
Durot, Eric
Roos-Weil, Damien
Chauchet, Adrien
Decroocq, Justine
Di Blasi, Roberta
Gastinne, Thomas
Bensaber, Hedi
Cheminant, Morgane
Jacquet, Caroline
Guidez, Stéphanie
Gros, François-Xavier
Bachy, Emmanuel
Coste, Arthur
Cony-Makhoul, Pascale
Treon, Steven P.
Delmer, Alain
Reshef, Ran
Le Gouill, Steven
Castillo, Jorge J.
Houot, Roch
Source :
Blood; 20240101, Issue: Preprints
Publication Year :
2024

Abstract

Histological transformation of Waldenström macroglobulinemia (HT-WM) carries a poor prognosis with standard treatments. Here, we report the first series of HT-WM treated with CAR T-cells showing a high efficacy and no unexpected toxicity.

Details

Language :
English
ISSN :
00064971 and 15280020
Issue :
Preprints
Database :
Supplemental Index
Journal :
Blood
Publication Type :
Periodical
Accession number :
ejs66195258
Full Text :
https://doi.org/10.1182/blood.2024024452