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Myosin-1C augments endothelial secretion of von Willebrand factor by linking contractile actomyosin machinery to the plasma membrane
- Source :
- Blood Advances; September 2024, Vol. 8 Issue: 17 p4714-4726, 13p
- Publication Year :
- 2024
-
Abstract
- •Myosin-1C is used for actomyosin-mediated expulsion of an essential blood clotting factor (VWF).•Myosin-1C links the exocytic actomyosin ring to PIP2 on the plasma membrane, forming anchor points that allow for maximal VWF secretion.
Details
- Language :
- English
- ISSN :
- 24739529 and 24739537
- Volume :
- 8
- Issue :
- 17
- Database :
- Supplemental Index
- Journal :
- Blood Advances
- Publication Type :
- Periodical
- Accession number :
- ejs66209167
- Full Text :
- https://doi.org/10.1182/bloodadvances.2024012590